Monoclonal Antibodies and Genetic Disease

Publications page

BOOKS

Epitope Mapping Protocols
(1996) edited by G.E. Morris, Humana Press (Methods in Mol. Biol. No. 66).

CONTRIBUTIONS TO BOOKS

  1. Epitope mapping of protein antigens by competition elisa G.E. Morris, in "The Protein Protocols Handbook" (ed. J.M. Walker) Humana Press, Totowa, NJ (1996) pp 595-600

  2. A rapid method for generating large numbers of high-affinity monoclonal antibodies from a single mouse Nguyen thi Man and G.E. Morris, in "The Protein Protocols Handbook" (ed. J.M. Walker) Humana Press, Totowa, NJ (1996) pp 783-792

  3. Production of antibodies by the hybridoma method Nguyen thi Man and G.E. Morris. in "Epitope Mapping Protocols" Humana Press (Methods in Mol. Biol. 66) (1996) pp. 377-389

  4. Epitope mapping by chemical fragmentation G.E. Morris. in "Epitope Mapping Protocols" Humana Press (Methods in Mol. Biol. 66) (1996) pp. 121-127

  5. Epitope mapping using naturally-occurring antigen variants G.E. Morris in "Epitope Mapping Protocols" Humana Press (Methods in Mol. Biol. 66) (1996) pp. 373-376

  6. Epitope mapping by transposon mutagenesis S.G. Sedgwick and G.E. Morris. in "Epitope Mapping Protocols" Humana Press (Methods in Mol. Biol. 66) (1996) pp. 343-353

  7. Reiterative screening of phage display peptide libraries for epitope mapping A. Pereboev and G.E. Morris. in "Epitope Mapping Protocols" Humana Press (Methods in Mol. Biol. 66) (1996) pp. 195-206

  8. Choosing a method for epitope mapping G.E. Morris in "Epitope Mapping Protocols" Humana Press (Methods in Mol. Biol. 66) (1996) pp. 1-9

  9. Epitope mapping G.E. Morris in "Immunochemical Protocols", 2nd Edn., Humana Press (Methods in Mol. Biol. 80) (1998) pp. 161-172

  10. Epitope mapping G.E. Morris in "Molecular Biomethods Handbook" (R. Rapley and J.M. Walker eds.) Humana Press (1998) pp. 619-630

  11. Epitope Mapping. G.E. Morris in "Encyclopaedia of Life Sciences" (2001) MacMillan Press, London.

  12. Epitope Mapping. G.E. Morris in "Encyclopaedia of Life Sciences" (2001) MacMillan Press, London.

  13. A rapid method for generating large numbers of high-affinity monoclonal antibodies from a single mouse. Nguyen thi Man and G.E. Morris, in "The Protein Protocols Handbook" 2nd Edn. (ed. J.M. Walker) Humana Press, Totowa, NJ (2002) pp 1129-38.

  14. The distibution of emerin and lamins in X-linked Emery-Dreifuss muscular dystrophy. G. E. Morris, S. Manilal, I. Holt, D. Tunnah, L. Clements, F.L. Wilkinson, C.A. Sewry and Nguyen thi Man. In "Dynamics of the Nuclear Envelope in Embryos and Somatic Cells" (ed. P. Collas) Landes Bioscience, Georgetown, TX (2002) pp.143-152.

  15. Protein interactions, right or wrong, in Emery-Dreifuss Muscular Dystrophy. G.E. Morris In "The Nuclear Envelope " (ed. Evans DE, Bryant JA and Hutchinson CJ) Symp Soc Exp Biol. 56 (2004) 57-68.

  16. Epitope mapping. G.E. Morris in "Immunochemical Protocols", 3rd edn., Humana Press Methods Mol Biol. 295 (2005) 255-268.

RESEARCH PAPERS

Structural changes in the C-terminal region of human brain creatine kinase studied with monoclonal antibodies.
Nguyen thi Man, A.J. Cartwright, M. Osborne and G.E. Morris, Biochim. Biophys. Acta, 1076 (1991) 245-251.

Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.
D.R. Love, G.E. Morris, J.M. Ellis, U. Fairbrother, R.F. Marsden, J.F. Bloomfield, Y.H. Edwards, C.L. Slater, D.J. Parry and K.E. Davies Proc. Natl Acad. Sci USA 88 (1991) 3243-3247.

Fetal dystrophin to diagnose carrier status.
I.B. Ginjaar, S. Soffers, A.F.M.Moorman, L.V.B. Nicholson, G.E. Morris, E. Bakker, A. van Haeringen and G.J.B. van Ommen, The Lancet 338 (1991) 258-259

Rapid mapping by transposon mutagenesis of epitopes on the muscular dystrophy protein, dystrophin.
S.G. Sedgwick, Nguyen thi Man, J.M. Ellis, H. Crowne and G.E. Morris, Nucleic Acids Research, 19 (1991) 5889-5894.

Identification by protein microsequencing of a proteinase V8 cleavage site in a folding intermediate of chick muscle creatine kinase.
G.E. Morris and P.J. Jackson, Biochemical J. 280 (1991) 809-811.

Structural relationships between hepatitis B surface antigen in human plasma and dimers of recombinant vaccine: a monoclonal antibody study.
Le Thiet Thanh, Nguyen thi Man, Buu Mat, Phan Ngoc Tran, Nguyen thi Vinh Ha and G.E. Morris, Virus Research 21 (1991).141-154.

Localization of the DMDL-gene-encoded dystrophin-related protein using a panel of 19 monoclonal antibodies. Presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles and in proliferating brain cell lines.
Nguyen thi Man, J.M. Ellis, D.R. Love, K.E. Davies, K.C. Gatter, G.Dickson and G.E. Morris, J. Cell Biol. 115 (1991) 1695-1700.

Retroviral-mediated transfer of a dystrophin minigene into mdx mouse myoblasts in vitro.
M.G. Dunckley, D.R. Love, K.E. Davies, F.S. Walsh, G.E. Morris and G. Dickson. FEBS Letters 296 (1992) 128-134.

A truncated dystrophin lacking the C-terminal domains is localized at the muscle membrane.
T.R. Helliwell, J.M. Ellis, R.C. Mountford, R.E. Appleton and G.E. Morris, American. J. Human. Genetics 50 (1992) 508-514.

Changes at the N-terminus of human brain creatine kinase during a transition between inactive folding intermediate and active enzyme.
G.E. Morris and Nguyen thi Man, Biochim.Biophys. Acta 1120 (1992) 233-238.

Immunoreactivity of skate electrocytes towards monoclonal antibodies against human dystrophin and dystrophin-related (DMDL) protein
M.J. Dowdall, J.M. Ellis, Nguyen thi Man and G.E. Morris Neuroscience Letters 138 (1992) 27-31.

Characterization of a 4.8kb transcript from the Duchenne muscular dystrophy locus expressed in Schwannoma cells.
D.J. Blake, D.R. Love, J. Tinsley, G.E. Morris, H. Turley, K. Gatter, G. Dickson, J. Morgan, Y.H. Edwards and K.E. Davies, Mol. Hum. Genet. 1 (1992) 103-109.

Myocardial dystrophin immunolocalization at sarcolemma and transverse tubules.
R.Yarom, G.E. Morris, R. Froede and J. Schaper, Experientia 48 (1992) 614-616.

Novel products of the dystrophin gene: a distal transcript initiated from a unique alternative first exon encoding a 75 kDa protein widely distributed in non-muscle tissues.
J.P. Hugnot, H. Gilgenkrantz, N. Vincent, P. Chafey, G.E. Morris, T. Monaco, Y. Berwald-Netter, A. Koulakoff, J.C. Kaplan, A. Kahn and J. Chelly. Proc Natl Acad Sci.USA, 89 (1992) 7506-7510.

71kD protein is a major product of the Duchenne Muscular Dystrophy gene in brain and other non-muscle tissues.
D. Lederfein, Z. Levy, N. Augier, J. Leger, G.E. Morris, O. Fuchs, D. Yaffe and U. Nudel. Proc Natl Acad Sci.USA, 89 (1992) 5346-5350.

Construction of dystrophin fusion proteins to raise targeted antibodies to different epitopes.
H.B. Ginjaar, H.B.M. van Paassen, J.T. den Dunnen, Nguyen thi Man, G.E. Morris, A.F.M.Moorman and G.J.B. van Ommen, FEBS Letters 308 (1992) 293-297.

Co-localization and molecular association of dystrophin with laminin at the surface of the mouse and human myotubes.
G. Dickson, A. Azad, G.E. Morris, H. Simon, M. Noursadeghi and F.S. Walsh, J.Cell Science 103 (1992) 1223-1234.

The dystrophin-related protein, utrophin, is expressed on the sarcolemma of regenerating muscle fibres in dystrophies and inflammatory myopathies.
T.R. Helliwell, Nguyen thi Man, G.E. Morris and K.E. Davies, Neuromus. Disorders 2 (1992) 177-184.

Monoclonal antibodies for dystrophin analysis: epitope mapping and improved binding to SDS-treated muscle sections.
Nguyen thi Man, H.B. Ginjaar, G.J.B. van Ommen and G.E. Morris, Biochem. J. 288 (1992) 663-668.

Utrophin, the autosomal homologue of dystrophin, is widely-expressed and membrane-associated in cultured cell lines.
Nguyen thi Man, Le Thiet Thanh, D.J. Blake, K.E. Davies and G.E. Morris, FEBS Lett., 313 (1992) 19-22.

Hepatitis B in Ho Chi Minh City, Viet Nam.
Tran van Be, Buu Mat, Nguyen thi Man and G.E. Morris, Trans. Roy. Soc Trop. Med. 87 (1993) 262.

Localization and quantitation of the chromosome-6-encoded dystrophin-like protein in normal and pathological human muscle.
G. Karpati, S. Carpenter, G.E. Morris, K.E. Davies, C. Guerin, and P. Holland, J. Neuropathol. Exp. Neurol., 52 (1993) 119-128.

A quantitative elisa for dystrophin.
G.E. Morris, J.M. Ellis and Nguyen thi Man, J. Immunol. Methods, 161 (1993) 23-28.

Use of epitope libraries to identify exon-specific monoclonal antibodies for characterization of altered dystrophins in muscular dystrophy.
Nguyen thi Man and G.E. Morris, American J. Human Genetics, 52 (1993) 1057-1066.

Monoclonal antibodies against the muscle-specific N-terminus of dystrophin: Characterization of dystrophin in a muscular dystrophy patient with a frameshift deletion of exons 3-7.
Le Thiet Thanh, Nguyen thi Man, D.R. Love, T.R. Helliwell, K.E. Davies and G.E. Morris, American J. Human Genetics 53 (1993) 131-139.

Dystrophin-related protein, utrophin, in normal and dystrophic human foetal skeletal muscle.
A. Clerk, G.E. Morris, V. Dubowitz, K.E. Davies, P.N. Strong and C.A. Sewry, Histochem. J. 25 (1993) 554-561.

Expression of the transcripts initiated in the 62nd intron of the dystrophin gene
M. Lambert, P. Chafey, J.P. Hugnot, A. Koulakoff, Y. Berwald-Netter, C. Billard, G.E. Morris, A. Kahn, J.C. Kaplan and H. Gilgenkrantz, Neuromusc. Disord. 3 (1993) 519-524.

Expression of the 43kD dystrophin-associated glycoprotein in human neuromuscular disease.
T.R. Helliwell, Nguyen thi Man and G.E. Morris, Neuromusc. Disord. 4 (1994) 101-113

Apo-dystrophin-1 and apo-dystrophin-2, products of the DMD locus: Expression during mouse embryogenesis and in cultured cell lines.
J. Schofield, D.J. Blake, G.E. Morris, C. Simmons, J. Tinsley, K.E. Davies and Y. Edwards, Hum. Mol. Genet., 3 (1994) 1309-1316.

Alpha-actinin in nemaline bodies in congenital nemaline myopathy: Immunological confirmation by light and electron microscopy.
C. Wallgren-Pettersson, B. Jasani, G.R. Newman, S. Jones, S. Singharao, G.E. Morris, A. Clarke, I. Virtanen, C. Holmberg and J. Rapola, Neuromusc. Disord. 5 (1995) 93-104.

Screening of donor blood for malaria by polymerase chain reaction.
Vu thi Ty Hang, Tran Van Be, Phan Ngoc Tran, Le Thiet Thanh, Luong Van Hien, E. O'Brien and G.E. Morris. Trans. Roy. Soc. Trop. Med. and Hyg., 89 (1995) 44-47.

Characterization of revertant muscle fibres in Duchenne Muscular Dystrophy using exon-specific monoclonal antibodies against dystrophin.
Le Thiet Thanh, Nguyen thi Man, T.R. Helliwell and G.E. Morris, American J. of Human Genetics 56 (1995) 725-731.

Full-length and short forms of utrophin, the dystrophin-related protein.
Nguyen thi Man, T.R. Helliwell, C. Simmons, S.J. Winder, J. Kendrick-Jones, K.E. Davies and G.E. Morris, FEBS Letters 358 (1995) 262-266.

A novel dystrophin isoform is required for normal retinal electrophysiology
V.N. d'Souza, Nguyen thi Man, G.E. Morris, W. Karges, D.M. Pillers and P.N. Ray, Human Molec. Genet. 4 (1995) 837-842.

Specificity and VH sequence of two monoclonal antibodies against the N-terminus of dystrophin.
G.E. Morris, C. Nguyen and Nguyen thi Man, Biochemical J. 309 (1995) 355-359.

Characterization of genetic deletions in Becker Muscular Dystrophy using monoclonal antibodies against a deletion-prone region of dystrophin.
Le Thiet Thanh, Nguyen thi Man, S. Hori, C.A. Sewry, V. Dubowitz and G.E. Morris, American J. of Medical Genetics 58 (1995) 177-186

The N-terminal half of dystrophin is protected from proteolysis in situ.
S. Hori, S. Ohtani, Nguyen thi Man and G.E. Morris, Biochem. Biophys. Res. Commun., 209 (1995) 1062-1067.

Epitope mapping of recombinant antigens by transposon mutagenesis
G.E. Morris, Nguyen thi Man and S.G. Sedgwick, Mol. Biotechnol. 4 (1995) 45-54.

Myoblast transfer in the treatment of Duchenne's Muscular Dystrophy.
J.R. Mendell, J.T. Kissel, A.A. Amato, W. King, L. Signore, T.W. Prior, Z. Sahenk, S. Benson, P.E. McAndrew, R. Rice, H. Nagaraja, R. Stephens, L. Lantry, G.E. Morris and A.H.M. Burghes. New England J. Med. 333 (1995) 832-838

Apo-dystrophins (Dp140 and Dp71) and dystrophin splicing isoforms in developing brain.
G.E. Morris, C. Simmons and Nguyen thi Man, Biochem. Biophys. Res. Commun. 215 (1995) 361-367.

A utrophin-glycoprotein complex in membranes of adherent cultured cells.
M. James, Nguyen thi Man, C.J. Wise, G.E. Jones and G.E. Morris.
Cell Motil. Cytoskeleton. 33 (1996) 163-174.

The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein.
S. Manilal, Nguyen thi Man, C.A. Sewry and G.E. Morris.
Human Molec. Genet. 5 (1996) 801-808.

 

Protease digestion studies of an equilibrium intermediate in the unfolding of creatine kinase
T. Webb, P.J. Jackson & G.E. Morris
Biochem. J. (1997) 321, 83-88

Diagnosis of X-linked Emery-Dreifuss Muscular Dystrophy by protein analysis of leucocytes and skin with monoclonal antibodies
S. Manilal, C.A. Sewry, Nguyen thi Man, F. Muntoni and G.E. Morris
Neuromusc. Disord. 7 (1997) 63-66

 

The molecular basis for cross-reaction of an anti-dystrophin antibody with alpha-actinin
Marian James, Nguyen thi Man, Yvonne H. Edwards and Glenn E. Morris
Biochim. Biophys. Acta 1360 (1997) 169-176.

Laminin-induced clustering of dystroglycan on embryonic muscle cells
M.W. Cohen, C. Jacobson, P.D. Yurchenko, G.E. Morris and S. Carbonetto
J. Cell Biol. 136 (1997) 1047-1058.

 

Dystrophin is replaced by utrophin in frog heart; implications for muscular dystrophy
G.E. Morris
Neuromuscular Disorders 7 (1997) 493-498.

Mutations in Emery-Dreifuss muscular dystrophy and their effects of emerin protein expression
S. Manilal, D. Recan, C.A. Sewry, M. Hoeltzenbein, S. Llense, F. Leturq, N. Deburgrave, J.-C. Barbot, Nguyen thi Man, F. Muntoni, M. Wehnert, J.-C. Kaplan and G. E. Morris
Human Molecular Genetics 7 (1998) 855-864.

 

Early presentation of X-linked Emery-Dreifuss muscular dystrophy resembling Limb-Girdle muscular dystrophy
F. Muntoni, E.J. Lichtarowicz-Krynska, C.A. Sewry, S. Manilal, D. Recan, S. Llense, J. Taylor, G. E. Morris and V. Dubowitz
Neuromuscular Disorders 8 (1998) 72-76.

An epitope structure for the C-terminal domain of dystrophin and utrophin
G.E. Morris, S. G. Sedgwick, J. M. Ellis, A. Pereboev, J. S. Chamberlain and Nguyen thi Man
Biochemistry 37 (1998) 11117-11127,

 

Identification of antigenic sites on three hepatitis C virus proteins using phage-displayed peptide libraries
L.A. Pereboeva, A.V. Pereboev and G.E. Morris
J. Med. Virol. 56 (1998) 105-111.

Colocalization of emerin and lamins in interphase nuclei and changes during mytosis
S. Manilal, Nguyen thi Man, Le Thanh Lam and G. E. Morris
Biochem. Biophys. Res. Commun. 249 (1998) 643-647.

 

Localization of myotonic dystrophy protein kinase in human and rabbit tissues using a new panel of monoclonal antibodies
Y.C.N. Pham, Nguyen thi Man, Le Thanh Lam and G. E. Morris
Hum. Mol. Genet. 7 (1998) 1957-1965.

Is myoblast transplantation effective?
T. Partridge, Q. Lu, G. E. Morris and E. Hoffmann
Nature Med. 4 (1998) 1208-1209.

 

Disruption of the utrophin-actin interaction by monoclonal antibodies and prediction of an actin-binding surface of utrophin
Morris,G.E., Nguyen thi Man, Nguyen thi Ngoc Huyen, A. Pereboev, J. Kendrick-Jones and Winder, S.J.
Biochem. J. 337 (1999) 119-123
 [PubMed abstract]  

Distribution of emerin and lamins in the heart and implications for Emery-Dreifuss Muscular Dystrophy
S. Manilal, C.A. Sewry, A. Pereboev, Nguyen thi Man, P. Gobbi, S. Hawkes, D.R. Love and G.E. Morris
Hum. Mol. Genet. 8 (1999) 353-359 [PubMed abstract]

 

Localization of rabbit huntingtin using a new panel of monoclonal antibodies.
F.L. Wilkinson, Nguyen thi Man, S.B. Manilal, P. Thomas, J.W. Neal, P.S. Harper, A.L. Jones and G.E. Morris. Molec. Brain. res. 69 (1999) 10-20 [PubMed abstract]

Molecular analysis of a spontaneous dystrophin "knockout" dog.
S.J. Schatzberg, N.J. Olby, M. Breen, L.V.B. Anderson, C.F. Langford, H.F. Dickens, S.D. Wilton, C.J. Zeiss, M.M. Binns, J.N. Kornegay, G.E. Morris and N.J.H. Sharp.
Neuromusc. Disord. 9 (1999) 289-295 [PubMed abstract] 

 

Heart to heart: from nuclear proteins to Emery-dreifuss muscular dystrophy.
G.E. Morris and S.Manilal
Hum. Mol. Genet. 8 (1999) 1847-1851[PubMed abstract]

Hepatitis C epitopes from phage-displayed cDNA libraries and their assembly into improved chimeric antigens.
L.A. Pereboeva, A. V. Pereboev, L. F. Wang and G.E. Morris
J. Med. Virol. 60 (2000) 144-151 [PubMed abstract] 

 

The human centromeric Survival Motor Neuron (SMN2) gene rescues embryonic lethality in Smn -/- mice and results in a mouse with Spinal Muscular Atrophy.
Monani, U.R., Sendtner, M., Coovert, D.D., Parsons, D.W., Andreassi, C., Le, T.T., Jablonka, S., Schrank, B., Rossol, W., Prior, T.W., Morris, G.E. and Burghes, A.F.M.
Hum. Mol. Genet. 9 (2000) 333-339 [PubMed abstract] 

Direct interaction between emerin and lamin A.
L. Clements, S. Manilal, D.R. Love and G.E. Morris.
Biochem. Biophys. Res. Commun. 267 (2000) 709-714.

 

Massive Idiosyncratic Exon Skipping Corrects The Nonsense Mutation In Dystrophic Mouse Muscle And Produces Functional Revertant Fibres By Clonal Expansion.
QL. Lu, GE. Morris, SD. Wilton, T. Ly, OV. Artem'yeva, P. Strong, TA. Partridge
J. Cell Biol. 148 (2000) 985-996.

Expression and Synthesis of Alternatively Spliced Variants of Dp71 in Adult Human Brain.
Austin, R.C., Morris, G.E., Howard, P.L., Klamut, H.J. and Ray, P.N.
Neuromusc. Disord. 10 (2000) 187-193.

 

The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells.
P.J. Young, T.T. Le, Nguyen thi Man, A.H.M. Burghes and G. E. Morris.
Exp. Cell Res. 256 (2000) 365-374.

New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1).
The International Myotonic Dystrophy Consortium.
Neurology 54 (2000) 1218-1221.

 

Nuclear proteins and cell death in inherited neuromuscular disease.
G. E. Morris.
Neuromusc. Disord. 10 (2000) 217-227.

In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide.
R.J. Bartlett, S. Stockinger, M.M. Denis, W.T. Bartlett, L. Inverardi, T.T. Le, Nguyen thi Man, G.E. Morris, D.J. Bogan, J. Metcalf-Brogan and J.N. Kornegay.
Nature Biotechnol. 18 (2000) 615-622.

 

Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart.
L. T. Lam, Y. C. N. Pham, Nguyen thi Man and G. E. Morris.
Hum. Mol. Genet. 9 (2000) 2167-2173.

Does the Survival Motor Neuron Protein (SMN) interact with Bcl-2?
D.D. Coovert, T.T. Le, G.E. Morris, Nguyen thi Man, M. Kralewski, M. Sendtner and A.H.M. Burghes.
J. Med. Genet. 37 (2000) 536-539.

 

The survival motor neuron (SMN) protein: effect of exon loss and mutation on protein localization.
T. T. Le, D. D. Coovert, U. R. Monani, G. E. Morris and A. H. M. Burghes.
Neurogenetics 3 (2000) 7-16 [PubMed Abstract]

The region of SMN protein encoded by exon 2b is involved in self-association and SIP1 binding.
P.J. Young, Nguyen thi Man, C. Lorson, T. T. Le, E. J. Androphy, A.H.M. Burghes and G.E. Morris.
Hum, Mol. Genet. 9 (2000) 2869-2877 [PubMed Abstract]

The structure of an intermediate in the unfolding of creatine kinase.
T. I. Webb and G. E. Morris.
Proteins 42 (2001) 269-278 [PubMed Abstract]

The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin.
I. Holt, L. Clements, S. Manilal, S. C. Brown and G. E. Morris.
Eur. J. Hum. Genet. 9 (2001) 204-208.

 

Nuclear gems and Cajal (coiled) bodies in foetal tissues: a nucleolar distribution for the spinal muscular atrophy protein, SMN.
P.J.Young, T.T. Le, M. Dunckley, Nguyen thi Man, A.H.M. Burghes and G.E. Morris.
Exp. Cell Res. 265 (2001) 252-261[PubMed Abstract]

Absence of utrophin in intercalated discs of human cardiac muscle.
C.A. Sewry, Nguyen thi Man, T. Lynch and G.E. Morris.
Histochem. J. 33 (2001) 9-12.

 

Epitopes in the interacting regions of beta-dystroglycan (PPxY motif) and dystrophin (WW domain).
Pereboev, A.V., Ahmed, N., Nguyen thi Man and Morris, G.E.
Biochim. Biophys. Acta 1527 (2001) 54-60 [PubMed Abstract]

Skeletal muscle pathology in autosomal dominant Emery-Dreifuss muscular dystrophy with lamin A/C mutations.
Sewry, CA, Brown, SC, Mercuri, E, Bonne, G, Camici, G, Feng, L, Morris, GE and Muntoni, F.
Neuropath. Appl. Neurobiol. 27 (2001) 281-290.

 

Dystrophin in Adult Zebrafish Muscle
S.P. Chambers, A. Dodd, R. Overall, T. Sirey, L. T. Lam, G. E. Morris, D.R. Love.
Biochem. Biophys. Res. Commun. 286 (2001) 278-283 [PubMed Abstract]

How does a g993t mutation in the emerin gene cause Emery-Dreifuss muscular dystrophy?
I. Holt, L. Clements, S. Manilal and G. E. Morris.
Biochem. Biophys. Res. Commun. 286 (2001) 1129-1133.

 

The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy.
G.E. Morris.
Trends Mol. Med. 7 (2001) 572-577 [PubMed Abstract]

Both emerin and lamin C depend on lamin A for localization at the nuclear envelope.
Vaughan OA, Alvarez-Reyes M, Bridger JM, Broers JLV, Ramaekers FCS, Wehnert M, Morris GE, Whitfield WGF, Hutchison CJ.
J. Cell Sci. 114 (2001) 2577-2590.

 

Co-localization of survival of motor neuron (SMN) protein and p53 in Cajal bodies.
P.J. Young, P.M. Day, J. Zhou, E. J. Androphy, G.E. Morris and C.L. Lorson.
J. Biol. Chem. 277 (2002) 2852-2859 [PubMed Abstract]

Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation.
E. Gussoni, R. R. Bennett, I. Gilgoff, J. Stein, Y. Chan, K. R. Muskiewicz, H. G. Lidov, C. Bönneman, A.von Moers, G. E. Morris, J. S. Chamberlain, L. M. Kunkel and K. Weinberg. J. Clin. Invest. 110 (2002) 807-814 [PubMed Abstract]

 

Changes in DMPK levels and muscle development in congenital myotonic dystrophy.
D. Furling, L.T. Lam, O. Agbulut, G. S. Butler-Browne and G. E. Morris. Amer J. Pathol. 162 (2003) 1001-9 [PubMed Abstract]

Emerin interacts invitro with the splicing-associated factor YT-521B.
F. L. Wilkinson, J. Holaska, Z. Zhang, A. Sharma, S. Manilal, I. Holt, S. Stamm, K. L. Wilson and G. E. Morris. Eur J. Biochem 270 (2003) 2459-66 [
PubMed Abstract]

The effect of pathogenic missense mutations in lamin A on its interaction with emerin,
I. Holt, C. Östlund, C. L. Stewart, Nguyen thi Man, H.J. Worman and G.E. Morris. J.
Cell Science 116 (2003) 3027-35 [PubMed Abstract]

Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse
Lu QL, Mann CJ, Lou F, Bou-Gharios G, Morris GE, Xue SA, Fletcher S, Partridge TA, Wilton SD.
Nature Medicine 9 (2003) 1009-101

A lamin A/C beta-strand containing the site of lipodystrophy mutations is a major surface epitope for a new panel of monoclonal antibodies.
Manilal S, Randles KN, Aunac C, Nguyen thi Man and Morris GE. Biochimica Biophysica Acta 1671 (2004) 87-92 [PubMed Abstract]


Monitoring of recombinant survival motor neuron protein using fiber-optic surface plasmon resonance.
Masson JF, Barnhart M, Battaglia TM, Morris GE, Nieman RA, Young PJ, Lorson CL, Booksh KS.
The Analyst 129, 855-859.

Indoprofen Upregulates the Survival Motor Neuron (SMN) Protein through a Cyclooxygenase-Independent Mechanism.
Lunn, MR, Root, DE, Martino, AM, Flaherty, SP, Kelley, BP, Coovert, DD, Burghes, AHM, Nguyen thi Man, Morris, GE, Zhou, J, Androphy, EJ, Sumner,CJ, Fischbeck, KH and Stockwell, BR
Chemistry and Biology, 11 (2004) 1489-1493.

Phase I study of dystrophin plasmid-based gene therapy in Duchenne/Becker muscular dystrophy.
Romero NB, Braun S, Benveniste O, Leturcq F, Hogrel JY, Morris GE, Barois A, Eymard B, Payan C, Ortega V, Boch AL, Lejean L, Thioudellet C, Mourot B, Escot C, Choquel A, Recan D, Kaplan JC, Dickson G, Klatzmann D, Molinier-Frenckel V, Guillet JG, Squiban P, Herson S, Fardeau M. Hum Gene Ther. 15 (2004) 1065-76.

Protein interactions, right or wrong, in Emery-Dreifuss muscular dystrophy. Morris GE. Symp Soc Exp Biol. 56 (2004) 57-68.

Strand bias in oligonucleotide-mediated dystrophin gene editing.
Bertoni C, Morris GE, Rando TA.
Hum Mol Genet 14 (2005) 221-33 [PubMed Abstract]

Matrix Metalloproteinase-1 Associates with Intracellular Organelles and Confers Resistance to Lamin A/C Degradation during Apoptosis.
Limb GA, Matter K, Murphy G, Cambrey AD, Bishop PN, Morris GE, Khaw PT
Amer J Pathol. 166 (2005) 1555-1563.


Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies.Pham YC, Nguyen thi Man, Holt I, Sewry CA, Pall G, Johnson K, Morris GE. J Cell Biochem. 95 (2005) 990-1001.

A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells. Sharma A, Lambrechts A, Hao le T, Le TT, Sewry CA, Ampe C, Burghes AH, Morris GE. Exp Cell Res.309 (2005) 185-197.

The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking. Tunnah D, Sewry CA, Vaux D, Schirmer EC, Morris GE. J Mol Histol. 36 (2005) 337-344.

Lamin A/C assembly defects in Emery-Dreifuss muscular dystrophy can be regulated by culture medium composition. Holt I, Nguyen TM, Wehnert M, Morris GE. Neuromuscul Disord. 16 (2006) 368-373.

Workshop on the nuclear envelope and Emery-Dreifuss muscular dystrophy 29th March 2006, Oswestry, UK. Randles KN, Morris GE. Neuromuscul Disord. 16 (2006) 608-612.

Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan. Xiong H, Kobayashi K, Tachikawa M, Manya H, Takeda S, Chiyonobu T, Fujikake N, Wang F, Nishimoto A, Morris GE, Nagai Y, Kanagawa M, Endo T, Toda T. Biochem Biophys Res Commun. 350 (2006) 935-941.

Primary laminopathy fibroblasts display altered genome organization and apoptosis. Meaburn KJ, Cabuy E, Bonne G, Levy N, Morris GE, Novelli G, Kill IR, Bridger JM. Aging Cell. 6 (2007) 139-153.

Endosomal location of dopamine receptors in neuronal cell cytoplasm. Wolstencroft EC, Simic G, thi Man N, Holt I, Lam le T, Buckland PR, Morris GE. J Mol Histol. 2007 Aug;38(4):333-40.

Absence of gemin5 from SMN complexes in nuclear Cajal bodies. Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE. BMC Cell Biol. 2007 Jul 18;8:28.

Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles Holt I, Mittal S, Furling D, Butler-Browne GS, Brook JD, Morris GE. Genes Cells. 2007 Sep;12(9):1035-48.

EMBL/GenBank Database submissions

  1. Z6661 VH sequence of mAb, MANEX1A, against dystrophin. 1995.
  2. Z6662 VH sequence of mAb, MANEX1B, against dystrophin. 1995.
  3. Z68204 Human mitochondrial succinyl CoA synthetase (partial sequence). 1996.
  4. Z74047 Dengue virus subtype 1 capsid protein and membrane pre-protein. 1996.
  5. Z74048 Dengue virus subtype 2 capsid protein and membrane pre-protein. 1996.
  6. AF250871 Human myotonic dystrophy kinase-related CDC42-binding protein kinase alpha (partial sequence). 2000.

This page is maintained by Glenn Morris and was last modified on 15th March 2008