The Wolfson Centre for Inherited Neuromuscular Disease
The Wolfson Centre is committed to finding new treatments for inherited neuromuscular disease by bringing together three disciplines under one roof in the new, purpose-built TORCH Building
Clinical Research (Head: Dr. Ros Quinlivan)
Muscle Pathology Research (Head: Prof. Caroline Sewry)
Laboratory Research (Head: Prof. Glenn Morris)
The Neuromuscular Research Laboratory
Our aim is to produce monoclonal antibodies as highly-specific research tools for analysis of molecular mechanisms in the pathogenesis of human genetic disease and for improved diagnosis. This involves producing large numbers of antibodies and identifying their binding sites on the protein antigen by a variety of epitope mapping techniques. The Group has an extensive network of clinical and scientific collaborators in hospitals, universities and research institutes in the USA, Canada, Japan, New Zealand, VietNam, Israel, Europe and the UK. We have a special interest in neuromuscular disease. Current research grant funding is provided by the Jennifer Trust, the American Muscular Dystrophy Association, AFM (Association Francaise contre les Myopathies) and the NINDS-NIH "SMA Project". We also have a long association with medical centres in VietNam, offering help with training and with development of modern diagnostic methods for muscular dystrophy, hepatitis, malaria and dengue fever; this work is supported by Medical and Scientific Aid to VietNam, Laos and Cambodia.
Specialized equipment available includes a cell culture suite, a fluorescence photomicroscope with image analysis, a BioRad Radiance 2000 confocal microscope, a Leica SP5 confocal microscope, a BIAcore-X biosensor for biomolecular interaction analysis, ABI nanospray QTrap 3200 and MALDI 4800 Mass Spectrometers and a range of preparative ultracentrifuges.
Tel. 01691 404155 (+44 1691 404155)
Fax 01691 404170 (+44 1691 404170)